I've not tried separate 'squirt-in' sealant before, but it's pretty much 'plug'n'play' I'd imagine. I have used 'Slime' inner tubes before, which come pre-filled with a similar liquid. They are heavier, which makes the bike feel slightly less responsive when accelerating but not a big deal. Probably better than getting a puncture, though I don't bother these days, (tempting fate) I don't find that I get that many. I wouldn't put it in my lightweight road wheels, but if your bike is anything else, you might as well give it a go.