So P&L hasn't had one like this for a while. Some interesting debates in the past at the time of Professor Nutt. Basically this one has been coming for years and I'm even sort of surprised to see the day arrive. For years there has been research into ketamine and similar substances to be used as a so called antidepressant. https://www.theguardian.com/science/2019/mar/23/ketamine-can-it-really-be-antidepressant Many alternative articles exist, I've chosen this one as it's a mix of news reporting, cases and facts. Groundbreaking stuff as the first licenced medication for decades in a new class of drugs (SSRIs although 'new' are decades old and many don't regard 'newer' SNRIs as a separate class). Whatever your opinion on that it uses a completely different receptor to the other five (some say four) classes of so called antidepressants. Was licenced earlier in March. Hopefully the UK will follow in a year or two. There are other forms and similar classes in the pipeline. I do worry about people trying to self medicate and get ketamine through illegal channels on the street or dark web, but I don't think there's very much you can do about that beyond a certain amount and this may have a very positive impact on people's lives and move us in the right direction on medication research. Of course, it's very expensive, so it may be 5-20 years away from making a big impact on what is called Treatment Resistant Depression (which is a scarily large group of people for anyone underplaying it).