I have that 48/16 and it caused 2 chains to grow a serious (3 cm up and down difference) tension variation, in two halves of the links. One explanation I found is that an integer ratio causes same chain links engaging at peak force (left and right pedal) moments.48x16 fixed on my lovely Boardman. I can happiliy do a 200k Audax with that setup
Anything similar experienced?