I went for a Secteur over a Defy for a couple of reasons.
In the Defy's favour was slightly better spec (this was 2010MY) and both of my previous bikes were Giants. Conversely, I thought the Secteur looked sweeter and the geometry was slightly more relaxed to allow space for, being blunt, my excessive paunch.
The thing that swung it, though, was that my local Giant stockist wouldn't let me take it out of the shop, whereas the local Spesh stockist told me to take it out for as long as I wanted and to bring it back "later".
Which brings me (almost) neatly to the main point. Without knowing what size you are (body:legs ratio, torso length, reach, weight etc), where you ride, what you plan to ride for and how long, it's difficult to suggest anything beyond "Get a test ride". There's only one person who knows what is comfortable for you and that is, unfortunately, you.