Once the tire is inflated, you may see that it is not as round as the rim is. Usually this will take the form of having most of the circumference of the tire in the correct place, but there will likely be one place where the tire either bulges out too far, or dips inward toward the rim. It may do this on only one side.
Most tires have a "witness line" moulded into each sidewall. This is a narrow ridge of rubber running around the side of the tire, just outside of the rim. Spinning the wheel and observing the witness line will help you locate the place where the seating might be off. Note, it could be OK on one side of the tire but not the other.
Seating A Bulging Tire
If one part of the tire bulges out farther than the rest, deflate it right away or it may explode with a loud bang! Manually re-arrange the tire to get it centered on the rim before re-inflating it. Make sure the tire bead isn't sitting on top of part of the inner tube.
If the bulge is right at the valve, this usually indicates that the tire is sitting on the reinforcing patch at the base of the valve. Completely deflate the tire, and push the valve up into the tire with your thumb, while pressing the tire down around it, then pull the valve back down before inflating. Seating a Tire that Dips Inward
If your tire dips inward at one spot, it is usually a sign of an unusually tight fit. This may make it a bit of a struggle to install the tire, but it also means that you can get away with considerable overinflation with no risk of blowing the tire off the rim. Indeed, the best way to seat a "dipping" tire is by temporariliy overinflating it until it "pops" into position. In some cases it may be beneficial to lubricate the side of the tire. This can be done with soapy water, but I usually use spray window cleaner for this, because it doesn't leave a soapy residue on the braking surface of the rim.