Depends on the bike what it will take but I, at least, lighten myself in the saddle over most blemishes.
Couple of months ago on the night ride I hit a pothole full on, never saw it at all. I was travelling at pace, fully in saddle and going slightly uphill, so plenty of weight on backwheel:-
Bike - pinch puncture rear wheel, broken spoke rear wheel, rim cracked around 5 nipple holes rear wheel, rear wheel out of true. Handlebars moved a bit as well, light mounts swiveled.
Me - jarred everything, damaged existing injury to left elbow, was like a balloon by next evening. Hurt my neck and back and had a pretty sore bum as well.