Earlier this year, I had an Orbea Avant M20D for testing and I really loved it. Had to give it back eventually but not before I'd clocked up nearly 1,000km on it. It's fast, very comfortable and rather nice looking. Also has the ability to take bespoke mudguards and rack that Orbea make (although I didn't test these as they weren't in stock). The M30D is a fair bit cheaper and almost identical (same frame) except that it comes with 105 rather than Ultegra, and frankly, if I were buying, that's the one I'd choose. I'd definitely recommend trying one if you can find a stockist.
That said, my current ride is a Giant Defy Advanced Pro 0 and that's a smashing bike too, so I would definitely endorse your choice. Similarly good for comfort over long distances while also being fairly quick, and the D-Fuse seatpost is brilliant. Main differences with the ones you've listed are Ultegra Di2 and fancy wheels, but they all have the same frame and finishing kit, and as
@vickster says, the Advanced Pro 3 looks like the 'sweet spot' with 105.
Also look at the Trek Domane 4.3 Disc - I did a 600km audax on one this year and it was fantastic. Great price too - well within your budget. Only downside is hybrid brakes (TRP Hy/Rd), but you could upgrade to the 4.5 for full hydros & Ultegra for £2,200.