I've done some of it, the bits between Marple and to near Crewe. It's great, the first part is either tarmac or hardpacked. Beyond Macclesfield it's a bit more grassy and can get muddy. I was on a MTB with slicks and was fine.
There's great industrial heritage to see with locks, mills, bridges etc.
I would do it mid week as it can get busy with walkers. In fact, a good time to do it is February or March time, you get the boat owners tinkering away on their boats, the smells of wood burning stoves and a real sense of community.
There a a couple of good cafe stops en route, to cater for the boat owners.
It's good to get a different viewpoint of the houses and scenery.
Recommended.