Having just gone clipless after 25 years of toeclips I'm still at the setup stage. 2nd ride today, 17 miles after a 10 mile amble to build up slowly. I've made what I think is a final coarse adjustment today, bringing the cleats further towards the balls of my foot and skewing the alignment more to match my pigeony feet! I do now have some unusual muscle tenderness from just above the back of the knee up but no pain in knees or joints just the kind you get from pressing different muscles into service. It's worse on my left leg than my right. My right is normally pulled into the toeclip tight so doesn't rotate but my left is looser and so had a tendency to rotate further out with me correcting my foot position now and again. I hope my final adjustments will now ease this and at the moment I'm thinking that the muscles will get used to the cleats. I might even be using some muscles to pull 'around' that I hadn't been using before, especially with my left leg. Just wondered if anyone who'd swopped to them had had similiar experiences and if anyone had any useful tips on cleat alignment?