My commute is Pontypridd - Cardiff on the trail (in winter) on my Ti road bike with... you guessed it, Gatorskins 700x25. Have gone as far as Abercynon and the bike/tyre combo is absolutely fine.
Unlike some others I like Gatorskins. Did the Tour of Flanders on them this year - 150Km over huge cobbles with 25% sections - and they were great.