I had a Italia gel flo saddle, one of those odd split ones and it was hell on earth. I tried lots with 'cut outs' to no avail. In the end, loosing weight was the best thing that improved my saddle comfort, not the pressure, but the reduction in padding around my sit bones.
Now, a San marco regal is, as they've named it 'the Belgian sofa'. But it would be no doubt uncomfy for someone else.