Especially on drop bars, too big a top tube length will tend to have you reaching far forward with more of your weight continuously on your hands as a consequence, even given that you may try to vary position by riding on the hoods occasionally (not good if your ability to brake is compromised by doing so). Riding any distance like that will tend to give you sore hands if you are at all succeptible to them. Reaching further forward also means your head will be lower, which in turn can give you a crick in your neck as you're constantly raising your head to get an adequate view of the road.
This is one of the reasons for the number of people who dislike drop bars and who prefer straight bars instead with their more upright riding position.