I own a shaft drive bicycle, supplied by zero bicycles in the UK. I have used the bicycle for my 22 mile per day commute and can report that I can perceive no difference between riding the Zero and my ladies Raleigh. The bike is designed to be a commuter bike, so comparing it with anything other is not really fair.
I love the shaft drive concept and hub gears, they are so clean, they don't need constant interference, they don't have a chain to fall off, you can change gear at standstill and they make the bike look clean and unfussy. For commuting, I doubt that many people would want more than 7 gears. Replacing the rear wheel is also fairly easy and clean!
I think that the main reason the bikes won't catch on is because they are expensive and they aren't supplied by many shops.