I was always advised to run a derailleur chain as straight as possible whatever gear arrangement I am in, thus avoiding unnecessary wear and tear on the chain links and sprocket teeth. I've worked on what I call the 'rule of threes', i.e., if on the big chainring, stay on the top three sprockets on the cassette / freewheel, middle chainring, the middle three sprockets etc.. But with the huge leaps and bounds in cycle drivetrain techno, does this guidance still apply - ? I read somewhere recently that apparently it is less important and I commonly see road bikes being ridden completely cross chained, i.e., big chainring and bottom gear on a nine speed cassette.