Bear in mind that it's not all about weight saved at the rim. This sort of thing gets discussed endlessly on Weightweenies and the like, complete with differential equations and everything. The consensus is that the any real difference is down to the overall weight of the wheel, which, as a proportion of bike plus rider, is absolutely miniscule. The micro-accelerations you might get when stamping on the pedals with the lower inertia rim gets cancelled out by the flywheel effect, with Aero effectively trumping weight on anything up to 10% climbs. Remember that some of the fastest wheels measured (and backed up by reality-testing) are Mavic Cosmics - even the alloy ones weighing in at 1800gms. Stiffness is pretty important though, and that's what you're really going to notice. So even a modest set of 'handbuilts' - say Open Pro on Hope/Novatech with spoke tension dialled in by a builder who knows your weight and what the wheels are going to be subjected to, can be made to feel very stiff. Of course you'd also need to treat yourself to some fast race tyres - say Veloflexes, Open Corsas, Conti GPs or ProRaces and some light tubes. Pump 'em up hard, so they make a nice humming noise on tarmac and you'll certainly notice a difference.
And sorry to be pedantic, but it's spelled K-s-y-r-i-u-m (you don't pronounce the 'K').