I don't think people level humour at the little old lady who goes to church every week for 60 years, or the man attending Friday prayers.
They launch it towards the people that 'lord' it over these 'real' people - the pope, the bishops, the dodgy kiddy-fiddling priests, the abusive reform school nuns, the Iman with one eye, one hand, one boll*ck......the list goes on.
'Real' people just going about their faith in peace and quiet is one thing....spreading hate and inciting hatred towards a group of people (gay/lesbian) in the name of religion (which is make believe) is a totally different kettle of eggs.