It's as much as makes no difference really. So long as the overall big:big and small:small is within the capacity of the derailleur, allowing for swapping around of cassettes and rings.
However as an engineer, I believe that running the transmission so that the derailleur spring tension is not running at its limit, improves the life of the chain and toothed parts as well as the chain.
However it is not beyond reason to run more than one chain depending on the requirements of your gearing throughout the year. The KMC split-links make this an easy prospect. It is also possible to run two chains at the same time, one cleaned ready for use whilst using the other, just swap them around when it comes to cleaning time. This has the benefit of keeping the wear on teeth to a minimum. My present transmission, Campag 10-speed, is five years old and shows no sign of excessive wear, I just keep on replacing chains.