Yes indeed.
I once rolled up to Liverpool Street station to catch a train to Harwich for the ferry. Unfortunately there were no trains from L'pool St. due to Olympic preparations,and I was told to go to Stratford. I had no map, but just thought there are plenty of people to ask for directions in London

. Anyway, I made it to Stratford Station where I was told there would be no trains from there either, but I would get a train at Ingatestone. I still didn't have a map although I had a compass, and Ingatestone wasn't so far away so I set off roughly eastwards. I found it impossible to buy a map without going into a shopping centre and that would have meant leaving the bike with full touring load unprotected for 30 minutes or so

. I was assured by several locals who I'd asked for directions that it was physically impossible to cycle as far as Ingatestone. Another warned me that my tyres would wear out over such a distance and I'd have to be prepared to buy replacements. One guy assured me I was on the right track but failed to instruct me which way to turn at the t junction just a couple of hundred metres down the road

.
Anyway, IME it's the lack of local knowledge that is the worst part of cycling in London, it is difficult to be concentrating on the actual cycling when struggling with navigation, and you'll be very lucky indeed to find any locals capable of assisting with directions.