If you are only interested in Di2 vs cable then read no further!
If you are also interested in the more general experience of switching between very different gearing systems... read on!
I have bikes with... Campagnolo Ergopower (3*10), Shimano Rapidfire (3*9), Shimano Tiagra (2*10), SRAM Apex (1*11)... and a Frankenstein DIY system (1*6) which uses a bar-end shifter on the left (wrong) side of the handlebar (because the right hand side was already used by a bar-end mirror).
Every time I switch to a different bike there is an adjustment period during which I get used to the replacement system. This normally only takes a few minutes. I have found, however, that a degree of concentration is involved. As long as I don't get distracted I am fine. A few times though I have let my mind wander and then my thumbs can start reaching for the Campagnolo thumb shifters even when not on that bike! That is because about 90% of my adult riding has been on Ergopower-ed bikes.
TBH, I would probably switch to electronic shifting if I could afford to, but there isn't much chance of that unless one of my little projects eventually earns me a decent supplement to my state pension.