I've flown to either Geneva, Lyon, Munich, Milan or Zurich and picked up a hire car. When young, before kids and full of life/energy, I used to drive it in one hit; as a family, we've driven several times, taking our time and staying in Campanile or Formule1 (+ the occasional posh hotel) to make the journey part of the fun.
I've never used the train but would love to, as it is reported to be very civilised, the reports I got recently are that Mrs Mate sat watching films, mate was on internet, kids played like at home rather than fighting and arguing. If you sort a hire car or taxi/train/bus the other end, or are off on your bikes, then it's got to be one of the best ways to travel.
If you're in a position to do it, I would go for it - it's on my list of opportunities missed and I will aim to achieve it some day.