When I was an avid motorcyclist there was a piece about killer pillars, it showed how the increased safety of cars has increased the size of the A pillers to a point where is the angles are right you can loose an entire car in this blind spot (it certainly changed the way I approach roundabouts, and that change has stuck).
Also my last car was a 2.5 ton 4x4, which was fitted out for offroad use (and used offroad), lifted, snorkeled, extra running lights, and spots. The running joke by other owners was that we had a cloaking device fitted, because the number of normal cars that just pulled out as if you weren't there was amazing, and we are expecting driver to see us on our little bikes!
Lights, hi-vis, none of it makes a jot of difference if the driver is not seeing you, and looked but did not see comes higher on the list of accident causes than speeding.