I measured how fat some 60mm Big Apples actually were a while back. First I took a wheel out the rear triangle and measured the width of the chain and seat stays where the tyre sits, then I measured the clearance left when the tyre was in there (this was just with a tape measure). Subtracting clearance from the width, it was pretty much 60mm spot on. I repeated this with a couple of other tyres (Surly Knard and Dirt Wizard) and got similar results.
I know the manufacturers measurements are nominal, and also other factors like pressure and rim width will have a slight bearing, but unless you're really trying to push it, I would take them as given and allow a few mm as appropriate for error (less for road tyres than MTB I'm guessing).
/doh - just noticed it's depth. I would think it scales similarly to the width...incidentally, Surly gives tyres 'geometries' on their website, including depth, but it's almost only their fat tyres. The 42mm Knard looks like it's 47.5mm deep on 24mm rims, with 41mm or 42mm width, depending whether you measure casing or knobbles.