I would suggest taking a link out personally.
Not a direct answer to your question, but you're getting into the areas of extreme cross chaining, ie, small/small & large/large generally are not good combinations, this also can cause excessive wear on your drive chain. This doesn't mean you can never use those combinations but they're not ideal.
It also depends on the chain line of the bike, how the front
rings line up with the back in a straight line.
You could possibly increase peddling resistance too due to the extremes of cross chaining!
With a tripple or double chainrings I would suggest you can achieve nearly all the combinations of gears without actually
cross chaining!