My sister spends a couple of days a week in London. It's all on expenses but like many jobs they are do-able from anywhere. She and her hubby don't have kids though, so I can't see a job like that working if you have a family.
In a previous job I had to drive to South Wales on a regular basis, with young kids - I even had to do S. Wales and back in a day with 8 hours work down near Cardiff. My wife went nuts... 16 plus hour day with hard driving through the middle of Wales - at least the driving kept you awake, not like on a Motorway.
Personally, I like living next to the Peaks and a stones throw from North Wales.