Sometimes when in the big/big cog combination the chain will rub the front mech causing a chattering (I know its a no no but in the real world this combo does get used), on 105 and above there is a trim facility that moves the front mech inboard by about 3mm to reduce/stop this from happening?
I must live in the real world then, as I never ride big big or the other way around, why would you?