Fatigue is the hardest thing to deal with, in my opinion. I often get asked to get people riding up to 200 miles in one go, and my advice is always that fuelling is the main thing to concern themselves with up to 100 miles, as soon as we get to the 150-200 mile distances, it’s the fatigue and the fueling in unison, that’s the bugger. If you run short of fuel, eating something, and backing off a bit works, when the fatigue hits, you can’t do anything to help it, other than stop, and rest. Whether you get the fatigue on a long ride, or because of several rides, undertaken without sufficient recovery in between, the advice is the same, only sufficient rest will help.