Team Sky, Brailsford and doping

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User169

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Genetic doping is a current issue!

I can't see your article - 30EUR is a bit much for me. Nevertheless, I'd be really surprised if anyone were really doing this. I'd be even more surprised if it were working.

Gene therapies are not trivial to make and there aren't that many people that know how to use them. There are just so many questions, not least what do you use as the target gene. What do you then use as vector - viral or non-viral, if viral, what virus - lentivirus, adenovirus, HSV - or are you going for naked DNA? What promoter are you going to use - constitutive, inducible (good luck with that one)? Once you've got your therapy together, how, when, where are you going to administer it? Once you've got it in, will you be able to shut it off?

It would be monumentally expensive - you'd have to start up your own research program effectively.

I reckon there's still more mileage in small molecules and recombinant proteins.
 
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