How big is your bladder, or do you relieve yourself in a bottle as you trundle down the M-Way? Most of us would follow the advice to take a break every couple of hours, if not to replenish ourselves and stretch our legs, but to check the vehicle.
With an EV, you'd use that opportunity to recharge the battery. It just needs a change of mindset.
BTW, my background is road haulage where a 800Km (500 mile) day was pretty common. I also used to regularly drive from Bristol or London home near Dundee after a day's work. I'm fairly sure that if I was still doing that sort of work, I could change my travel to accommodate using an EV, especially now as usable ranges are increasing.
Ford are getting there
https://www.ford.co.uk/future-vehicles/new-e-transit