I use DT shifters daily on my bike with a 10 speed 12-30 block at the back, and it's fine. I do have to make sure that I get into gear when approaching hills, as it can be difficult to change gear sometimes, and on occasion I do find that I've not quite got the gear change right, so it shifts when I stand up and push hard, but overall, it's a system I'm happy with as it's totally maintenance free, and I don't have to worry about setting up the indexing properly ever.
On the other hand sometimes dropping a gear on a hill can be problematic, especially if (as I am wont to do) I am standing. So often I end up treating the bike as semi-fixed gear. I will probably end up changing the gears over to being STIs, as I think ten speed is pretty much the limit of the range I can get out of the shifters, and I have the remaining 11 speed bits from my 105 groupset to put on at some point.