Thanks for all the info. I run a 30 year old MTB with 18 gears (Uniglide/Biopace). Suddenly I don't feel quite so guilty for occasionally running in large outer front ring and large inner rear sprocket occasionally.
I'm considering getting a modern hack for everyday use so the 'retro' can have an easier life in old age (some drivetrain parts are getting rare too, so lowering wear would help). Poss new or nearly new, but not big money. A MTB mainly for road, but preferably with no more than 18 gears - as I'm too lazy to swap through more. Definitely want Shimano, etc quality drivetrain - but lots of new 18 gear bike seem to have cheap gears.