It's a very personal journey, each human anatomy can be very different.
I loved my Turbo saddle in the 1980's, which I could ride 200+ miles in a day without any problems, but I was under 11 stone and young. I re-tried a Turbo again a few years ago, it was very uncomfy, terrible saddle for me nowadays.
The
Spa Nidd is one of my favourite saddles, I can ride all day with no problems, I also have a Brook B17, which I like too.
Big leather saddles seem to be a good choice for big fat old blokes like me, so I've also been using a Selle Italia Storica leather saddle on my Ti bike, which I quite like, only problem is that it squeaks.
Selle Italia Storica leather saddle:
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